AVDB: The Arab Variation and Disease Burden

The Arab Variant and Disease Burden Database (AVDB) is a comprehensive and publicly accessible platform designed to facilitate the exploration of gene- and variant-level insights derived from Arab population cohorts, starting with Emirati population. AVDB provides users with summarised data regarding gene-level carrier frequencies, pathogenic allele counts, and associated disorders, along with clinically relevant annotations for variants and their inclusion in screening panels based on the ACMG/AMP guidelines. Researchers, clinicians, and public health professionals can utilize this database to assess carrier risk, evaluate potential at-risk couples based on population genetics models, and examine curated lists of genes prioritized for national screening initiatives. Furthermore, the platform includes machine learning-derived risk scores to enhance gene prioritization in clinical and public health contexts

AVDB is an essential resource for advancing precision medicine and population genomics within the Arab world, enabling data-driven decision-making pertinent to genetic screening, disease prevention, and the development of health policies.